A review of the Phyllanthus genus plants: Their phytochemistry, traditional uses, and potential inhibition of xanthine oxidase

Hyperuricemia is a risk factor for gout and other cardiovascular diseases. One of the therapies used Allopurinol. Unfortunately, it has unwanted side effects. These conditions made researchers continue to seek develop alternative treatments from natural products. which plants Phyllanthus genus. their contents was polyphenols, especially flavonoids. It an treatment hyperuricemia because its minimal The flavonoids in this genus were reported have xanthine oxidase inhibitory: quercetin, kaempferol, rutin, apigenin, luteolin, myricetin, catechin, epicatechin, epigallocatechin with IC 50 values ​​from 0.44 M > 100μM. presence π-π interactions between planar rings A C on flavones phe 1009 914 addition hydroxyl groups flavonoid compounds plays crucial role inhibiting oxidase.